Kluyvera Infections in Humans: A Systematic Review
Abstract
Objective: Kluyvera species are Gram-negative rods, catalase-positive, oxidase-negative, and glucose-fermenting members of the Enterobacteriaceae family. Although often considered saprophytic, Kluyvera can cause opportunistic infections, particularly in immunocompromised individuals, with severe underlying medical conditions. The objective of this study was to identify and evaluate all published cases of human infections by Kluyvera spp., through a systematic literature review.
Methods: We searched PubMed and Scopus databases for articles providing data related to the epidemiology, clinical features, and microbiology of Kluyvera human infections.
Results: In total, 73 studies provided information on 97 patients with Kluyvera infections. The mean age of the patients was 39.5 years and most (53.6%) were females. The most frequently reported types of infection were bacteremia, urinary tract infections, intra-abdominal infections, and soft tissue infections, and more than half of them were community-acquired. Comorbidities were common in majority of the patients, and almost half of these were immunosuppressed. K. ascorbata was the most commonly identified species (59.8%), followed by Kluyvera cryocrescens (23.7%), Kluyvera intermedia (3.1%), and Kluyvera georgiana (1.0%). High rates of resistance were recorded for ampicillin (78.1%), 1st-generation cephalosporins (52.1%), and 2nd-generation cephalosporins (43.8%). Third-generation cephalosporins were the most commonly used…
How strong is the evidence?
Evidence Hub reads this as a systematic review, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 97 participants or records.
Read the paper
Related studies
- Association of lower urinary tract symptoms and OAB severity with quality of life and mental health in China, Taiwan and South Korea: results from a cross-sectional, population-based study
- Ten-Day Quadruple Therapy Comprising Low-Dose Rabeprazole, Bismuth, Amoxicillin, and Tetracycline Is an Effective and Safe First-Line Treatment for Helicobacter pylori Infection in a Population with High Antibiotic Resistance: a Prospective, Multicenter, Randomized, Parallel-Controlled Clinical Trial in China
- The Role of the NLR and PLR in Urinary Tract Infection
- Threat of Antimicrobial Resistance among Pilgrims with Infectious Diseases during Hajj: Lessons Learnt from COVID-19 Pandemic
- Leclercia adecarboxylata urinary tract infection in a patient with bladder cancer and recurrent hematuria
- A Case Series of Staphylococcus lugdunensis Infection in Cancer Patients at an Academic Cancer Institute in the United States
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.