Interaction between quercetin and DNA
Abstract
Studies on the interaction between small organic molecules and DNA are important means to explore drug mechanism and new drugs. Quercetin is a polyhydroxy flavone compound with activities such as anti-cancer, anti-inflammatory, antibacterial, antiviral, hypoglycemic and anti-hypertensive, immunomodulation and cardiovascular protection. Experimental studies aim at confirming if an interaction exists between quercetin and DNA, and determining the type of interaction. The interaction between quercetin and herring DNA can be detected by fluorescence spectrometry and resonance scattering fluorescence spectrometry analysis. The mode of the interaction between quercetin and herring DNA can be detected by UV-Vis spectrophotometry and fluorescence polarization analysis. This review helps understand the in vitro interaction between quercetin and DNA, and assist the development of drugs for corresponding diseases.
有机小分子与 DNA 相互作用机理研究已经成为药物作用机理研究与新药筛选的重要手段之一。槲皮素(Quercetin) 是一种多羟基黄酮类化合物，具有抗癌、抗炎、抗菌、抗病毒、降糖降压、免疫调节及保护心血管的作用。实验研究的目的是发现与确认槲皮素与DNA 之间是否具有相互作用，以及确定其相互作用的类型。根据荧光光谱法和共振散射荧光光谱法的分析结果，发现槲皮素与鲱鱼精DNA 之间存在相互作用；使用紫外-可见分光光度法和荧光偏振分析，发现槲皮素与鲱鱼精DNA 之间的相互作用模式不属于嵌插作用，而是沟槽嵌合或者静电相互作用；最后通过分子对接实验，成功佐证槲皮素与鲱鱼精DNA 之间的相互作用模式是沟槽结合。该工作有利于理解槲皮素与DNA 之间的体外作用方式，助力于相应疾病的药物开发。.
Read the paper
Related studies
- Quercetin Influences Quorum Sensing in Food Borne Bacteria: In-Vitro and In-Silico Evidence
- Phenolic-protein interactions: insight from in-silico analyses – a review
- In Silico Discovery of Candidate Drugs against Covid-19
- Neuropharmacological Effects of Quercetin: A Literature-Based Review
- In vitro and in silico anti-dengue activity of compounds obtained from Psidium guajava through bioprospecting
- Effect of Quercetin Rich Onion Extracts on Bacterial Quorum Sensing
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.