Quercetin induces p53‐independent cancer cell death through lysosome activation by the transcription factor EB and Reactive Oxygen Species‐dependent ferroptosis
Abstract
Cancer cells exhibit more dependence on iron and enhanced sensitivity to iron‐dependent, programmed cell death (ferroptosis) than normal cells. Quercetin exerts anti‐cancer effects, but the underlying molecular mechanism is largely unknown. In this study, we aimed to investigate the involvement of lysosome function and ferroptosis in the anti‐cancer potential of quercetin.
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