Effect of Combined Exercise, Heat, and Quercetin Supplementation on Whole Body Stress Response
Abstract
The purpose of this study is to determine whether dietary quercetin supplementation effects thermotolerance and heat acclimation in human subjects exposed to exercise/heat stress.
Specific Aim I. To determine if quercetin in combination with repeated bouts of thermally stressful exercise will impact intestinal barrier function. The investigators will examine urinary lactulose excretion, plasma endotoxin,plasma quercetin, inflammatory cytokines (TNF-a \& Il-6), anti-inflammatory cytokines (Il-10), and HSP70 and HSF-1 content of peripheral blood mononuclear cells.
Specific Aim II. To determine whether quercetin's suppresses the ability of human subjects to acclimate to exercise/heat stress. The investigators will examine body temperatures, heart rates, physiological strain, sweat and plasma volume responses to standardized heat tolerance tests.
Conditions: Heat Acclimation and Thermotolerance.
Primary outcome: Urinary Lactulose Excretion; Plasma endotoxin; Plasma Quercetin; Plasma TNF-a; plasma Il-6; Plasma Il-10; HSP70 content of peripheral blood mononuclear cells; HSF-1 content of peripheral blood mononuclear cells; Core temperature response to heat tolerance test; Skin temperature response to heat tolerance test; Mean body temperature response to heat tolerance test; Heart rate response to heat tolerance test; Physiological strain response to heat tolerance test; Urinary Lactulose Excretion; Urinary Lactulose Excretion; Plasma Quercetin; Plasma Quercetin; Plasma Endotoxin;…
How strong is the evidence?
Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 9 participants or records.
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