Hypoxia-inducible Transcription Factor 1 (HIF-1) in Vascular Aging
Abstract
The purpose of this study is to find out if quercetin can increase blood levels of hypoxia-inducible transcription factor 1 (HIF-1 protein) and to see if there is a corresponding increase in blood flow to the brain.
Conditions: Stroke, Problem of Aging.
Primary outcome: Define change from baseline levels of HIF-1 concentration and 3 of its regulated proteins after 6 months of quercetin (versus placebo) dietary intake.; Determine change from baseline brain blood flow after 6 months of quercetin (versus placebo) dietary intake..
Enrollment: 106 participants.
How strong is the evidence?
Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 106 participants or records.
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