Global trends and research profile of antibiotic heteroresistance: a bibliometric and visual analysis
Abstract
Introduction: Antibiotic heteroresistance challenges clinical treatment, risking adverse outcomes and antimicrobial resistance emergence. This study aims to explore its research status and trends.
Methods: We screened global publications on antibiotic heteroresistance from the Web of Science Core Collection, Scopus and PubMed databases. Bibliometrix and VOSviewer were used to conduct the bibliometric and visual analysis of the publications.
Results: In total, 1516 publications on antibiotic heteroresistance were included. The number of publications and citations increased with time, most notably in the last two decades. Among the 377 sources, the most active and most cited journal was Antimicrobial Agents and Chemotherapy. The most productive and most cited author were Michael J. Rybak and Keiichi Hiramatsu, respectively.Emory University and Monash University were the institutions with the most publications and citations, respectively. The USA had the highest publications and citations. Emory University and Monash University were the institutions with the most publications and citations, respectively. The USA had the highest publications and citations. A total of 1758 author keywords and five main clusters were identified, including heteroresistance terms cluster, Gram-positive bacteria cluster, Gram-negative bacteria cluster, Mycobacterium tuberculosis cluster and antifungal heteroresistance cluster. The top ten antibiotics and microorganisms with keywords co-occurrence…
How strong is the evidence?
Evidence Hub reads this as a systematic review. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
Read the paper
Related studies
- Severe clinical outcomes of COVID-19 associated with proton pump inhibitors: a nationwide cohort study with propensity score matching
- Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model
- Association between cord blood 25-hydroxyvitamin D concentrations and respiratory tract infections in the first 6 months of age in a Korean population: a birth cohort study (COCOA)
- Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli
- Neuroprotective Effects of Epicatechin against Oxidative Stress-Induced Cognitive Impairment: A Systematic Review and Meta-Analysis
- Photochemical behavior of levofloxacin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.