Quercetin inhibits the growth of triple-negative breast cancer via the AKT1 pathway
Abstract
Abstract Triple-negative breast cancer (TNBC) is associated with a poor prognosis and lacks effective drugs. Quercetin (QUE), a dietary flavonoid compound, exhibits excellent anticancer activities. However, the effects and underlying mechanisms of QUE against TNBC remain unclear.This study aims to determine the role and regulation of AKT1 expression for QUE-mediated TNBC progression. Here, We found that QUE exhibited significant suppressive effects on the proliferation for TNBC cells, while inducing apoptosis. Transcriptome sequencing identified AKT1 as a crucial biomarker of TNBC. High AKT1 expression in TNBC tissues was correlated with poor patient prognosis and its knockdown reversed the inhibitory effect of QUE on TNBC progression. Mechanism exploration revealed that QUE interacted with AKT1 and suppressed the phosphorylation of AKT1, leading to the β-catenin nuclear translocation inhibition. In conclusion, Our findings revealed that AKT1 plays an important role in TNBC and is a novel therapeutic target of QUE treatment.
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