Deciphering Liver-Kidney Meridian Tropism and Shared Molecular Modules of Antitumor Herbal Medicines in Ovarian, Cervical, and Bladder Cancers
Abstract
Abstract OBJECTIVE To characterize meridian tropism patterns of antitumor traditional Chinese medicines (TCM) and to explore the computational molecular basis by which the liver-kidney meridian combination may support the TCM principle of“same treatment for different diseases”in ovarian, cervical, and bladder cancers. METHODS A total of 354 antitumor TCMs and 5,471 constituents were collected. Data mining, network construction, network pharmacology, molecular docking, Kaplan-Meier survival analysis, and TCGA data analysis were performed to explore meridian distribution, core compounds, targets, prognostic significance, and stage-specific expression of hub genes. RESULTS The top five meridians of antitumor TCMs were liver (21.20%), lung (16.40%), spleen (13.40%), stomach (13.20%), and kidney (10.40%). Ovarian, cervical, and bladder cancers formed the largest tumor cluster (43%), with corresponding herbs targeting the liver-kidney meridian combination. The top five key compounds were β-sitosterol, quercetin, linoleic acid, palmitic acid, and vanillic acid. Twenty-one core targets were identified, with AKT1, MYC, TP53, EGF, and MMP9 as hubs. KEGG enrichment showed involvement in PI3K-Akt pathway, platinum resistance, etc. β-sitosterol had strong binding affinity with core targets (strongest with AKT1, -33.36 kcal/mol). Survival analysis showed MYC and EGF high expression correlated with poorer pan-cancer and target tumor survival, while AKT1, TP53, and MMP9 had tumor-specific…
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