Quercetin Reduces Vascular Permeability in an Experimental Rat Model of Ovarian Hyperstimulation Syndrome: A Comparative Histochemical and Immunohistochemical Study with Cabergoline
Abstract
Abstract This study investigated the effects of quercetin and cabergoline on ovarian histomorphology, biochemical changes and the vascular endothelial growth factor (VEGF)–pigment epithelium-derived factor (PEDF)- cyclooxygenase-2 (COX-2) axis in an experimental rat model of ovarian hiperstimulation syndrome (OHSS). Forty-two immature female Wistar rats were randomly divided into six groups: Control, OHSS, Quercetin, Cabergoline, OHSS+Quercetin, and OHSS+Cabergoline. Ovarian morphology was assessed by measuring ovarian weight and diameter. Histological examination was performed with hematoxylin and eosin (H&E) staining, and immunohistochemical analyses were conducted to determine VEGF, PEDF, and COX-2 expression in ovarian tissue. Vascular permeability was evaluated spectrophotometrically using Evans Blue dye extravasation, while serum TNF-α and estradiol levels were determined by ELISA. The OHSS group showed significantly increased ovarian weight and diameter compared with the other groups. VEGF and COX-2 expression were increased, whereas PEDF immunoreactivity was reduced in granulosa cells. In the treatment groups, VEGF and COX-2 expression were similar patterns, but PEDF expression was higher in the OHSS+Cabergoline group. Vascular permeability was significantly lower in the OHSS+Quercetin group than in the OHSS+Cabergoline group, indicating a stronger protective effect of quercetin on vascular integrity. Quercetin reduced vascular permeability, although most…
How strong is the evidence?
Evidence Hub reads this as a preprint, done in animal, not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Quercetin Influences Quorum Sensing in Food Borne Bacteria: In-Vitro and In-Silico Evidence
- Phenolic-protein interactions: insight from in-silico analyses – a review
- In Silico Discovery of Candidate Drugs against Covid-19
- Neuropharmacological Effects of Quercetin: A Literature-Based Review
- In vitro and in silico anti-dengue activity of compounds obtained from Psidium guajava through bioprospecting
- Effect of Quercetin Rich Onion Extracts on Bacterial Quorum Sensing
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.