Phytochemical Composition and Cosmeceutical-Related Bioactivities of Canscora lucidissima (H. Lév. & Vaniot) Hand.-Mazz
Abstract
Abstract Canscora lucidissima (H. Lév. & Vaniot) Hand.-Mazz. is a Vietnamese ethnomedicinal plant traditionally associated with anti-inflammatory use, yet its cosmeceutical potential remains poorly defined. This study provides an integrated evaluation of the phytochemical composition and cosmeceutical-related bioactivities of C. lucidissima solvent extracts, including antioxidant capacity, enzyme inhibitory, and antibacterial effects, together with in silico analyses of the identified phytochemicals covering molecular interactions, electronic features, and predicted ADME properties. Among the extracts, ethyl acetate showed the most consistent bioactivity profile, with the strongest tyrosinase inhibition (IC₅₀ = 195.24 µg/mL), α-amylase inhibition, DPPH and ABTS radical-scavenging activities, and antibacterial effects against Staphylococcus aureus and Escherichia coli . The ethanol extract exhibited the highest α-glucosidase inhibition (IC₅₀ = 96.46 µg/mL). Phytochemical screening and UHPLC-based quantification revealed a solvent-dependent distribution of secondary metabolites. PCA and Pearson correlation analyses associated the enhanced responses of this fraction with phenolic/flavonoid enrichment, particularly catechin, chlorogenic acid, rutin, quercitrin, and quercetin. Molecular docking against tyrosinase 5NN8 identified rutin, caffeine, quercitrin, and chlorogenic acid as the most relevant candidate ligands, with rutin showing the strongest predicted affinity and…
How strong is the evidence?
Evidence Hub reads this as a preprint, done in computer models (in silico), not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Quercetin Influences Quorum Sensing in Food Borne Bacteria: In-Vitro and In-Silico Evidence
- Phenolic-protein interactions: insight from in-silico analyses – a review
- In Silico Discovery of Candidate Drugs against Covid-19
- Neuropharmacological Effects of Quercetin: A Literature-Based Review
- In vitro and in silico anti-dengue activity of compounds obtained from Psidium guajava through bioprospecting
- Effect of Quercetin Rich Onion Extracts on Bacterial Quorum Sensing
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.