Protective Effects of HPTLC-Characterized Prosopis juliflora Hydro-Alcoholic Extract with Quantified Quercetin on High-Fat Diet-Induced Hepatic Injury, Dyslipidemia, and Cardiac Stress in Rats
Abstract
Abstract Background Herbal remedies form a cornerstone of traditional medical systems. Prosopis juliflora is valued in Ayurveda and Traditional Chinese Medicine for its wound-healing, anti-inflammatory, and antioxidant properties. However, its potential role in preventing nonalcoholic fatty liver disease (NAFLD) remains largely unexplored. Purpose This study aims to assess the protective effect of a hydro-alcoholic extract from Prosopis Juliflora aerial part against NAFLD brought on by a high-fat meal. Method Male Wistar albino rats were administered a high-fat diet (HFD) concomitantly with the hydro-alcoholic extract of Prosopis juliflora aerial parts (500 mg/kg) or atorvastatin (30 mg/kg) for 84 days, beginning on Day 1. Normal control animals received standard chow with 1% CMC. At the end of the experimental period, animals were euthanized, and blood and liver tissues were collected for analysis. Serum biochemical markers were quantified, and liver specimens were processed for histopathological evaluation. Result HPTLC analysis revealed a characteristic fingerprint with nine peaks and a quercetin content of 0.27%. HFD feeding significantly increased body weight, liver enzymes, bilirubin, CK-MB, and dyslipidemia (p P. juliflora extract significantly attenuated these alterations (p Conclusion The HPTLC-characterized P. juliflora hydro-alcoholic extract exerts potent hepatoprotective, hypolipidemic, and cardioprotective effects in HFD-fed rats, supporting its potential as a…
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