Neuroprotective Effects of Quercetin in Neonatal Hypoxic-Ischemic Brain Injury: A Meta-analysis
Abstract
Abstract Objective This study assesses the neuroprotective potential of quercetin in preclinical models of neonatal hypoxic-ischemic brain injury (HIBI) and its role as a possible enhancer of therapeutic hypothermia. Study Design A systematic review of 8 preclinical studies was conducted per PRISMA guidelines, sourced from PubMed, Scopus, and Web of Science, with a random-effects meta-analysis. Results Quercetin significantly lowered infarct volume, seizure susceptibility, and inflammation (pooled standardized mean differences [SMD] = 1.29; 95% confidence interval [CI]: 1.00–1.58; p 30 mg/kg, SMD = 1.65) and intraperitoneal (IP) administration (SMD = 1.42) outperformed lower doses or intravenous (IV) routes (SMD = 0.95). Rat models showed greater benefits (SMD = 1.38) than piglets (SMD = 0.85). Moderate heterogeneity ( I 2 = 45%) was noted, but sensitivity analysis confirmed robustness (SMD = 1.20). Publication bias was minimal ( p = 0.12). Conclusion Quercetin offers notable neuroprotection in neonatal HIBI, with an optimal 40 mg/kg IP dose, suggesting it could complement hypothermia. Limited bioavailability and lack of long-term data call for further research in advanced models. Key Points Quercetin improves outcomes in neonatal HIBI. IP route shows greater efficacy. Higher doses (>30 mg/kg) are more effective. Meta-analysis confirms significant benefit (SMD = 1.29). Bioavailability remains a key translational barrier.
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in animal, not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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