Analysis of the efficacy and mechanism of action of Buzhong Yiqi Decoction on gastric cancer using meta-analysis and network pharmacology
Abstract
Background: To explore the efficacy and mechanism of Buzhong Yiqi Decoction (BZYQD) in the treatment of gastric cancer (GC) using meta-analysis and network pharmacology.
Methods: We searched PubMed, Embase, Cochrane Library, Chinese BioMedical Literature Database, China National Knowledge Infrastructure, China Science and Technology Journal (CQVIP), and Wanfang databases for randomized controlled trials that evaluated BZYQD therapy for GC. The outcomes were clinical efficacy, 2-year survival rate, Karnofsky performance status score, and incidence of adverse reactions. We performed a meta-analysis using RevMan 5.3 software. Then, the potential active ingredients and targets of BZYQD were screened through the Traditional Chinese Medicine Systems Pharmacology. GC-related targets were screened through the GeneCards database. The "active ingredients-targets" network was constructed by Cytoscape 3.8.0 software, and the protein-protein interaction network was constructed using the STRING database. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses of the effective targets of BZYQD in GC were performed through the Metascape platform. Finally, molecular docking technology was used to identify the affinity and activity between core targets and active compounds.
Results: A total of 15 randomized controlled trials were included in the literature. This literature included a total of 1176 patients, of whom 588 were in the treatment group and 588 were in the…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in computer models (in silico), not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health. Reported size: 1,176 participants or records.
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