Effects of resveratrol supplementation on multiple health outcomes: an umbrella review of systematic reviews and meta-analyses of randomized controlled trials
Abstract
BACKGROUND: Resveratrol has shown health benefits like anti-obesity, antioxidant, and anti-inflammatory effects. OBJECTIVES: To resolve conflicting findings and clarify its impact, our study summarizes resveratrol supplementation’s effects and evaluates its effectiveness across populations. METHODS: We conducted the search through PubMed, Embase, and Web of Science databases from inception to April 30th, 2025, to identify meta-analyses of randomized controlled trials examining the effects of resveratrol supplementation on human health. The quality of included studies was evaluated using the A Measurement Tool to Assess Systematic Reviews (AMSTAR) tool, and the credibility of evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) criteria. This study was registered in PROSPERO (CRD 42024554480). RESULTS: Forty-five systematic reviews with 129 associations between resveratrol supplementation and human health were included, which consists of 68 outcomes. Using the AMSTAR measurement tool, all articles were categorized as moderate-to-high quality. Among 35 significant associations, four were supported by high-certainty evidence according to GRADE, including positive effects of resveratrol supplementation on reducing waist circumference (mean difference [MD] = -0.80 cm, 95% CI = -1.40, -0.20), total cholesterol among overweight adults (MD = -0.19 mmol/L, 95% CI = -0.32, -0.06), diastolic blood pressure (MD = -3.55 mmHg, 95% CI…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
Read the paper
Related studies
- Quercetin Influences Quorum Sensing in Food Borne Bacteria: In-Vitro and In-Silico Evidence
- Phenolic-protein interactions: insight from in-silico analyses – a review
- In Silico Discovery of Candidate Drugs against Covid-19
- Neuropharmacological Effects of Quercetin: A Literature-Based Review
- In vitro and in silico anti-dengue activity of compounds obtained from Psidium guajava through bioprospecting
- Effect of Quercetin Rich Onion Extracts on Bacterial Quorum Sensing
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.