Effects of Moringa oleifera Lam. Supplementation on Cardiometabolic Outcomes: A Meta-Analysis of Randomized Controlled Trials with GRADE Assessment
Abstract
Background/Objectives:Moringa oleifera Lam. is traditionally used in African and Asian medicine for its nutritional and therapeutic properties. Rich in (poly)phenols, vitamins, and minerals, various parts of the plant were used to manage metabolic disorders. No systematic research critically evaluated its impact on cardiometabolic outcomes assessed through randomized controlled trials (RCTs), thus this study aimed to do so by synthesizing existing evidence. Methods: A systematic search of PubMed, Scopus, and Web of Science databases was conducted through 7 April 2025. Eligible RCTs with a minimum duration of two weeks that evaluated moringa supplementation in adults (≥18 years) and reported at least one cardiometabolic outcome, including anthropometric measures, lipid profile, glycemic indices, or blood pressure. Random-effects meta-analyses were performed using standardized mean differences, risk of bias was assessed using the Cochrane RoB 2 tool, while the certainty of evidence was evaluated using GRADE assessment. Results: Nine RCTs (12 study arms) involving 341 participants in the intervention and 308 in the control groups met inclusion criteria. Moringa supplementation showed no significant effects on most considered outcomes. A modest reduction in diastolic blood pressure (SMD: -0.41; 95% CI: -0.75 to -0.07; p = 0.02; I2 = 19%) was observed; however, this effect was not robust in sensitivity analyses. Subgroup analyses suggested potential benefits at doses I2…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 341 participants or records.
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