Antioxidant and anticancer properties of citrus-mediated nanoformulations revealed by meta-analysis
Abstract
This study aims to explore and analyse the potential antioxidant and anticancer potential of various citrus-mediated nanoformulations (CMNs), focusing on their effectiveness in scavenging free radicals and inducing cytotoxicity in cancer cells. This research employs a meta-analysis approach to assess data from multiple studies on CMNs. This study is the first meta-analysis to evaluate the antioxidant and anticancer properties of CMNs concurrently. This study offers a novel perspective by examining citrus species, plant parts utilised, nanoparticle types, particle sizes, and coating materials. The analysis employs the Population, Intervention, Comparison, and Outcome (PICO) framework and complies with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The analysis utilizes Hedges' effect size and includes validation through fail-safe N. The IC50 evaluation (µg/mL) revealed a significant effect of CMNs on antioxidant activity (d++ = 3.49; P ++ = 0.2; P = 0.309) and radical inhibition (%) for CMNs (d++ = 0.1; P = 0.602) did not significantly differ. Subgroup analysis provided further insights, showing that both citrus peel and polyvinyl alcohol significantly reduced IC50 values (d++ >1; P ++ = 3.05; P = 0.015), followed by those derived from Citrus limon (d++ = 2.25; P ++ = 1.03; P = 0.025). Various types of nanoformulations, such as Ag chitosan-NP (silver nanoparticle with chitosan), Ag-NP (silver nanoparticles), cerium dioxide…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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