Urate-lowering effects of polyphenolic compounds in animal models: systematic review and meta-analysis
Abstract
Background: Recent research underscores the critical role of uric acid (UA) in the pathogenesis and progression of various diseases. However, the effects of polyphenolic compounds on uric acid levels remain poorly defined.
Objective: This review aims to assess the impact of five specific polyphenolic compounds on uric acid levels in animal models.
Methodology: We performed an exhaustive literature search through October 30, 2024, utilizing databases including Wanfang, VIP, Cochrane Library, CNKI, Embase, and PubMed. The methodological quality of the included animal studies was evaluated using the SYRCLE (Systematic Review Centre for Laboratory animal Experimentation) risk of bias tool. Data analysis was conducted using R software, with meta-analyses performed via RevMan 5.3, adhering to the Cochrane Handbook for Systematic Reviews of Interventions.
Results: Our analysis integrated data from 49 studies, revealing that the selected polyphenolic compounds significantly lowered serum uric acid (SUA) levels across various animal models (standardized mean difference (SMD) = -2.33, 95% CI [-2.73, -1.93]) and increased urinary uric acid (UUA) levels (SMD = 2.53, 95% CI [1.38, 3.69]). Subgroup analyses demonstrated consistent SUA reduction across different disease models. Detailed meta-analyses for each polyphenol disclosed distinct contributions to SUA reduction: resveratrol (RES) (SMD = -1.86, 95% confidence interval (CI) [-2.28, -1.45]), chlorogenic acid (CGA) (SMD = -2.31, 95% CI…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in animal, not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Quercetin Influences Quorum Sensing in Food Borne Bacteria: In-Vitro and In-Silico Evidence
- Phenolic-protein interactions: insight from in-silico analyses – a review
- In Silico Discovery of Candidate Drugs against Covid-19
- Neuropharmacological Effects of Quercetin: A Literature-Based Review
- In vitro and in silico anti-dengue activity of compounds obtained from Psidium guajava through bioprospecting
- Effect of Quercetin Rich Onion Extracts on Bacterial Quorum Sensing
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.