The impact of Jinlida on blood glucose control and insulin resistance in patients with prediabetes and type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials
Abstract
Objective: To evaluate the efficacy and safety of Jinlida (JLD) in improving glycemic control and insulin resistance in patients with prediabetes (PD) and type 2 diabetes mellitus (T2DM) through a meta-analysis of randomized controlled trials (RCTs).
Methods: Databases including PubMed, Web of Science, Cochrane Library, Embase, Scopus, CBM, CNKI, Wanfang, and VIP were searched up to July 2025. Randomized controlled trials comparing JLD with controls were included. Pooled analyses were conducted using a random-effects model. Pre-specified subgroup analyses included health status and treatment duration. Additional analyses by baseline FBG level and age were performed to explore residual heterogeneity. Multivariable meta-regression with Knapp-Hartung adjustment further examined potential moderators (e.g., background therapy, baseline FBG level). Publication bias was assessed by funnel plots, Egger's test, and the trim-and-fill method. Risk of bias and evidence certainty were evaluated using RoB 2.0 and GRADE.
Results: A total of 20 RCTs involving 2,993 participants were included. Compared with controls, JLD significantly reduced: FBG (MD = -0.97, 95% CI: -1.40 to -0.53; p p CI: -1.00 to -0.52; p p CI: 0.12 to 0.32, p p p p < 0.001). Subgroup analyses revealed that JLD produced greater glycemic improvements in shorter-duration trials and in patients with higher baseline fasting glucose (≥10 mmol/L). T2DM patients showed more pronounced reductions in HbA1c, HOMA-IR, and lipid…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 2,993 participants or records.
Read the paper
Related studies
- Quercetin Influences Quorum Sensing in Food Borne Bacteria: In-Vitro and In-Silico Evidence
- Phenolic-protein interactions: insight from in-silico analyses – a review
- In Silico Discovery of Candidate Drugs against Covid-19
- Neuropharmacological Effects of Quercetin: A Literature-Based Review
- In vitro and in silico anti-dengue activity of compounds obtained from Psidium guajava through bioprospecting
- Effect of Quercetin Rich Onion Extracts on Bacterial Quorum Sensing
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.