Effects of Quercetin on Metabolic Dysfunction‐Associated Steatotic Liver Disease: A Systematic Review and Meta‐Analysis
Abstract
ABSTRACT This systematic review and meta‐analysis aimed to evaluate the effects of quercetin (QE) on liver function, lipid profiles, kidney function, anthropometric measures, hematological markers, and inflammatory markers in patients with metabolic dysfunction‐associated steatotic liver disease (MASLD). PubMed, Cochrane Library, Web of Science, and Embase were searched to January 26, 2025, for randomized controlled trials (RCTs). Additional gray literature sources, trial registries, and preprint platforms were screened. Weighted mean differences (WMDs) with 95% confidence intervals were calculated. Heterogeneity was assessed using the I 2 statistic, and meta‐regression analyses explored the influence of quercetin dose, baseline BMI, and age. Seven RCTs (540 patients) were included. Quercetin significantly reduced liver enzymes (ALT, AST, GGT), direct bilirubin, and C‐reactive protein. Lipid profiles improved with reductions in total cholesterol, LDL, and triglycerides, and an increase in HDL. No significant effects were observed on kidney function, BMI, body fat, hematological markers, or TNF‐α. Meta‐regressions suggested dosage, baseline BMI, and age may contribute to heterogeneity. According to GRADE, the certainty of evidence ranged from very low to moderate. QE shows preliminary evidence of improving liver function, lipid profiles, and inflammation in MASLD patients. However, given the small number of RCTs and the generally limited certainty of evidence, these findings…
How strong is the evidence?
Evidence Hub reads this as a systematic review, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 540 participants or records.
Read the paper
Related studies
- Quercetin Influences Quorum Sensing in Food Borne Bacteria: In-Vitro and In-Silico Evidence
- Phenolic-protein interactions: insight from in-silico analyses – a review
- In Silico Discovery of Candidate Drugs against Covid-19
- Neuropharmacological Effects of Quercetin: A Literature-Based Review
- In vitro and in silico anti-dengue activity of compounds obtained from Psidium guajava through bioprospecting
- Effect of Quercetin Rich Onion Extracts on Bacterial Quorum Sensing
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.