The effect of quercetin supplementation on the components of metabolic syndrome in adults: A systematic review and dose–response meta-analysis of randomized controlled trials

Nooshin Noshadi, Atefeh Bonyadian, Ali Hojati, Mahdieh Abbasalizad-Farhangi, Marzieh Heidari, Melika Darzi, Hooria seyedhosseini-Ghaheh, M. Khajeh et al.

Journal of Functional Foods, 2024

1,164 participants · 22 citations

Abstract

This systematic review and meta-analysis of randomized controlled trials (RCTs) sought to evaluate the effects of quercetin on the components of (MetS) such as waist circumference (WC), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBG), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C). A systematic literature search up to December 2023 was completed in Scopus, PubMed, Embase, and Web of Science, to identify eligible RCTs. Altogether, 20 studies with a total sample size of 1,164 subjects were included in the analysis. A pooled analysis showed that quercetin consumption led to a significant reduction in FBG (WMD: −1.03 mg/dL; 95 % CI: −1.87 to −0.19), and SBP (WMD: −1.96 mmHg; 95 % CI: −3.11 to −0.81). However, there were no significant effects on TG, HDL-C, WC, and DBP. It was found that quercetin intake can decrease FBG and SBP significantly without significant effects on other components of MetS.

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Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 1,164 participants or records.

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