Effect of quercetin supplementation on serum CRP levels: a systematic review and meta-analysis of randomized controlled trials
Abstract
Background: Several studies have investigated the effect of quericitn supplementation on serum C - reactive protein (CRP). However, results were inconsistent. This systematic review and meta-analysis was designed to assess the effect of quercetin supplementation on CRP levels in randomize control trials (RCTs). Method: We searched PubMed and Scopus up to July 2016 to identify RCTs investigating the effect of quercetin on serum CRP. Meta-analysis was performed using either a fixed-effects or random-effect model according to I ² statistic. Weighted mean differences (WMDs) and 95% confidence intervals (CIs) were calculated for net changes in CRP levels. Results : Seven trials with eight data sets and 346 participants met the inclusion criteria. There was no significant differences for CRP reduction between subjects with quercetin supplementation and placebo control [WMD, 0.01 mg/L; 95% CI: -0.18 to 0.21, p =0.88] with significant heterogeneity ( I ²=48.9%; p=0.05). Subgroup analyses showed that dose, duration and country were not the potential sources of heterogeneity. Conclusion: Our results suggest that quercetin supplementation does not reduce serum CRP. Further large and well-designed studies are necessary to confirm this conclusion.
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 346 participants or records.
Read the paper
Related studies
- Quercetin Influences Quorum Sensing in Food Borne Bacteria: In-Vitro and In-Silico Evidence
- Phenolic-protein interactions: insight from in-silico analyses – a review
- In Silico Discovery of Candidate Drugs against Covid-19
- Neuropharmacological Effects of Quercetin: A Literature-Based Review
- In vitro and in silico anti-dengue activity of compounds obtained from Psidium guajava through bioprospecting
- Effect of Quercetin Rich Onion Extracts on Bacterial Quorum Sensing
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.