Quercetin ingestion alters motor unit behavior and enhances improvement in muscle strength following resistance training in older adults: a randomized, double-blind, controlled trial
Abstract
BACKGROUND: During resistance training, quercetin ingestion can enhance motor unit (MU) with a higher recruitment threshold in older adults.
OBJECTIVE: We investigated the effects of daily quercetin glucoside ingestion on chronic adaptations in muscle strength and MU behavior following resistance training in healthy older adults.
METHODS: Twenty-six older adults were randomly allocated to two groups that completed 6-week resistance training intervention with the ingestion of either placebo (PLA) or quercetin glycosides (QUE) at 200 mg/day. Maximal voluntary force (MVF) during isometric knee extension, muscle mass, and MU firing behavior during ramp task at 70%MVF were measured before (PRE) and after (POST) intervention.
RESULTS: In both groups, knee extensor MVF was significantly increased (both p 0.050). At POST, firing rates of Mus with relatively moderate (recruited between 20 and 40%MVF) or higher (recruited between 20 and 40%MVF) recruitment thresholds were higher in QUE than PLA (p < 0.050). There was a significant correlation between %change in MVF and %change in firing rates of MUs with a relatively higher recruitment threshold from PRE to POST (p = 0.018, r = 0.642).
CONCLUSIONS: These results suggest that the adaptations of MUs with higher recruitment thresholds explain the greater improvement in muscle strength associated with QUE ingestion.
CLINICAL TRIAL REGISTRY: UMIN000053019 ( https://rctportal.niph.go.jp/detail/um?trial_id=UMIN000053019 ).
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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