Quercetin prophylaxis in prevention of acute mountain sickness (AMS): a randomized, double blind, placebo controlled phase-II clinical trials
Abstract
BACKGROUND: Acute Mountain sickness (AMS) is a common form of high altitude illnesses (HAI) primarily caused by hypobaric hypoxia. Proper acclimatization is crucial for enhancing the physiological adaptability during ascent to high altitudes (HA).
AIM: The present study aimed to evaluate the effectiveness of quercetin bar prophylaxis in preventing AMS during acclimatization to a high altitude environment.
DESIGN: A double blind, randomized, placebo-controlled trial.
METHODS: The study included 110 healthy lowland male subjects with age 26.86 ± 4.1 years (range between 20 and 40 years), who ascended from near sea level (440 m) to high altitude (3048 m) where they spent 6 days, thereafter further ascended to very high altitude (3750 m). The participants were randomly assigned in to two groups. Placebo group (n = 55, food bar without quercetin; identical in appearance, taste and smell) and Quercetin group (n = 55, food bar containing 500 mg quercetin). Subjects consumed one bar daily for 15 days, beginning two days prior to ascent and continued throughout the study period. Physiological parameters (SpO2, pulse rate, blood pressure), physical performance (six minute walk test), hematological variables (haemoglobin and haematocrit) and biochemical parameters were assessed at three different points i.e. at baseline (sea level), day 7 (at high altitude) and day 15 (at very high altitude). AMS incidence and severity were evaluated using the Lake Louise Scoring (LLS) system.
RESULTS:…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 55 participants or records.
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