The Effect of Microneedling Mesotherapy, Chemical Exfoliation and Combination Therapy on Selected Skin Parameters and Cutibacterium acnes Colonization in Women With Oily Skin
Abstract
Background: Oily skin is characterized by excessive sebum production and increased activity of Cutibacterium acnes.
Aims: To evaluate the effects of mandelic acid exfoliation, microneedle mesotherapy with a sebum-regulating ampoule, and combination therapy on skin parameters and C. acnes activity in women with oily skin.
Methods: Fifty-five women aged 18-47 were randomly assigned to three groups: microneedle mesotherapy (6 treatments), mandelic acid exfoliation (6 treatments), or combination therapy (3 exfoliations followed by 3 mesotherapy treatments). Skin hydration, sebum level, pH, and gloss were measured using an MPA Courage&Khazaka device. C. acnes activity was assessed indirectly by porphyrin fluorescence with a Visiopor device. Measurements were taken on the cheeks and in the T-zone before treatment (day 1), after three session (day 63), and after six sessions (day 126).
Results: Skin hydration increased significantly in all groups. Mesotherapy reduced sebum in the T-zone only after six treatments, while exfoliation reduced sebum mainly on the cheeks. Combination therapy resulted in the most extensive and stable sebum reduction in both areas. A temporary decrease in pH was observed after mesotherapy, with no pH changes after exfoliation or combination therapy. No significant changes in skin gloss were found. C. acnes colonization increased in the T-zone after mesotherapy, whereas exfoliation and combination therapy significantly reduced all colonization indices, with…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
Read the paper
Related studies
- Quercetin Influences Quorum Sensing in Food Borne Bacteria: In-Vitro and In-Silico Evidence
- Phenolic-protein interactions: insight from in-silico analyses – a review
- In Silico Discovery of Candidate Drugs against Covid-19
- Neuropharmacological Effects of Quercetin: A Literature-Based Review
- In vitro and in silico anti-dengue activity of compounds obtained from Psidium guajava through bioprospecting
- Effect of Quercetin Rich Onion Extracts on Bacterial Quorum Sensing
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.