The Combined Effects of an Anti-Inflammatory Diet and Curcumin Supplementation on Thyroid Function and Lipid Profile in Patients With Hashimoto's Thyroiditis: A Double Blind Randomised Clinical Trial
Abstract
Background: Hashimoto's thyroiditis (HT) is an inflammatory autoimmune disease and patients with HT may benefit from interventions that incorporate anti-inflammatory components. This study aimed to assess the combined effects of an anti-inflammatory diet and curcumin supplementation on thyroid hormones and lipid profile in patients with HT.
Methods: This randomised controlled clinical trial was conducted on 57 patients with HT. Patients were randomly assigned to receive either an anti-inflammatory diet plus 1320 mg/day curcumin or an anti-inflammatory diet plus placebo for 12 weeks. Anthropometric indices, anti-thyroid peroxidase (anti-TPO), thyroid-stimulating hormone (TSH), thyroxine (T4), triiodothyronine (T3), and lipid profile parameters were assessed at baseline and after the 12-week intervention. The trial was registered in the Clinical Trials Database (registration number NCT05975866).
Results: After 12 weeks of intervention, both groups showed reductions in waist circumference and waist-to-hip ratio, with greater changes observed in the curcumin group. However, between-group differences were not statistically significant. A significant reduction in anti-TPO levels was observed in the curcumin group compared to placebo (p = 0.006). Although TSH and T3 levels significantly decreased within the curcumin group (p = 0.014 and p = 0.001, respectively), between-group differences were not statistically significant after adjustment. Additionally, HDL-C levels showed a…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 57 participants or records.
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