Phenolic-rich extruded BRS 305 sorghum-based beverage improves fecal and blood metabolites, oxidative balance and cardiometabolic markers in adults with excess body weight: a single-blind, randomized, placebo-controlled study
Abstract
Purpose: To evaluate the impact of a phenolic-rich, extruded BRS305 sorghum-based beverage on fecal and blood metabolic, oxidative balance, and cardiometabolic parameters in adults with excess body weight.
Methods: In a single-blind, randomized, placebo-controlled study, 51 overweight adults of both sexes, were assigned to consume a sorghum beverage (SG, n = 25) or a control beverage (CG, n = 26), daily for 10 weeks, alongside a personalized hypocaloric diet (-500 kcal). The beverages phenolic profile was analyzed. Anthropometry, body composition, food intake, biochemicals, total plasma antioxidant capacity, oxidative stress, blood metabolite, fecal pH, short-chain fatty acids concentration, and Bristol stool scale were assessed at baseline and endpoint.
Results: The sorghum beverage exhibited high diversity of phenolic compounds, including phenolic acids, flavonoids, and tannins, which reflected in higher plasma concentrations of trans-caffeic acid and naringenin in SG at the endpoint compared to the CG, along with an increase in total plasma antioxidant capacity. In the SG, superoxide dismutase and malondialdehyde decreased in intra-group, while catalase decreased at delta. In contrast, CG decreased nitric oxide levels and increased body fat percentage in intra-group. SG decreased insulin, triglycerides, HOMA-IR, and TyG index intra-group, maintaining body fat percentage; increased HDL-c and decreased Castelli I index at the endpoint; and decreased Castelli II index at…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 51 participants or records.
Read the paper
Related studies
- Quercetin Influences Quorum Sensing in Food Borne Bacteria: In-Vitro and In-Silico Evidence
- Phenolic-protein interactions: insight from in-silico analyses – a review
- In Silico Discovery of Candidate Drugs against Covid-19
- Neuropharmacological Effects of Quercetin: A Literature-Based Review
- In vitro and in silico anti-dengue activity of compounds obtained from Psidium guajava through bioprospecting
- Effect of Quercetin Rich Onion Extracts on Bacterial Quorum Sensing
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.