Effects of Quercetin Supplementation on Oxidative Stress, Blood Pressure, Aerobic Power, Concentric Pathologic Hypertrophy and Cardiac Function in Men with Hypertension and Coronary Artery Disease After Percutaneous Coronary Intervention: a Randomized, Double-Blind Placebo-Controlled Trial
Abstract
Background and Objectives: The aim of this study was to investigate possible effects of quercetin supplementation on oxidative stress, blood pressure, aerobic power, concentric pathologic hypertrophy and cardiac function in men with hypertension and coronary artery disease (CAD) after percutaneous coronary intervention (PCI). Materials and Methods: The present study was a randomized, double-blind clinical trial; in which, 24 men with hypertension and CAD after PCI (aged 40–60 years) were participated. Patients were prescribed quercetin (250 mg/day) or placebo for two months. Plasma total antioxidant capacity (TAC) and malondialdehyde (MDA) were assessed using colorimetric methods as well as left ventricular diastolic dysfunction (LVDD), p wave depression (PWD), ejection fraction (EF) and E/A using echocardiography and WRp using Storer-Davise cycle test. Systolic and diastolic blood pressures were measured before and after the intervention. Data were analyzed using ANCOVA and paired-sample T-test. Results: Supplementation resulted in a significant improvement in oxidative stress reduction (TAC increased and MDA decreased), systolic and diastolic blood pressures, systolic (EF) and diastolic (E/A) functions and aerobic power, compared to pretest and placebo groups following eight weeks of treatment (p 0.05). The RWT was not significantly different between the quercetin and placebo groups (p > 0.05). Conclusions: Quercetin supplementation can improve oxidative stress, blood…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 24 participants or records.
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