Quercetin blocks senescence-related cardiorenal fibrosis induced by hypertension
Abstract
To multidimensionally analyze the clinical effects of Qianyang Yuyin Granules on elderly hypertensive patients through an "energy-inflammation-aging" network.
Methods: Relevant datasets were retrieved from the GEO database. Gene set enrichment analysis (GSEA) was performed on the gene expression profiles of peripheral blood cells from patients with essential hypertension in dataset GSE24752. The GSEA referenced "GO gene sets" and "KEGG gene sets" to identify significantly enriched gene sets. A clinical trial was conducted using a randomized controlled study design. A total of 40 patients meeting the inclusion criteria were enrolled. The control group received standard antihypertensive treatment with angiotensin receptor blockers (ARBs) or combined calcium channel blockers (CCBs). In contrast, the treatment group received Qianyang Yuyin Granules in addition to the standard treatment for 12 weeks. Blood pressure levels and clinical efficacy were observed, and changes in energy metabolism indicators, DNA damage markers, and senescence-associated secretory phenotype (SASP) in blood were measured using ELISA before and after treatment.
Results: GSEA results indicated significant energy metabolism dysregulation in hypertensive patients. Clinical findings showed that both groups achieved blood pressure control without significant intergroup differences (P > 0.05). In terms of clinical efficacy, the treatment group had a significantly higher effective rate compared to the control…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 40 participants or records.
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