Effect and safety of Neiguan acupoint injection with astragalus injection for chronic heart failure with qi-deficiency and blood-stasis syndrome: a randomized controlled trial
Abstract
Objective: To investigate the effect and safety of astragalus injection at Neiguan (PC6) for chronic heart failure (CHF; HF) with qi-deficiency and blood-stasis syndrome, and its effect on the renin-angiotensin-aldosterone system (RAAS).
Methods: A randomized, double-blind, placebo-controlled, parallel-group trial was conducted. Patients with CHF presenting with qi-deficiency and blood-stasis syndrome were randomly assigned in a 1:1 ratio to either the experimental group or control group using a random number table. The experimental group received conventional standard therapy plus astragalus injection at PC6, whereas the control group received conventional standard therapy plus placebo. Traditional Chinese Medicine (TCM) syndrome scores, B-type natriuretic peptide (BNP) levels, left ventricular ejection fraction (LVEF), Minnesota Living with Heart Failure Questionnaire (MLHFQ) scores, 6-min walk distance (6MWD), New York Heart Association (NYHA) functional class, plasma renin (PRA), angiotensin II (Ang II), aldosterone (ALD), were compared between groups at baseline and post-treatment. 3-month major adverse cardiac events (MACE), including all-cause mortality and HF-related readmission. Adverse events and safety indicators were also monitored.
Results: A total of 200 patients were included in the final analysis, 100 in each group. Baseline characteristics were not significantly different between the two groups (p > 0.05), except for the grouped distribution of patients…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 200 participants or records.
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