Corynebacterium amycolatum: An Emerging Pathogen in Chronic Otitis Media
Abstract
Background: Corynebacterium amycolatum has traditionally been considered a commensal organism of the skin and mucosa; however, recent reports suggest its emerging role as a true pathogen in chronic otitis media (COM). Understanding its microbiological characteristics and resistance profile is essential for guiding effective antimicrobial therapy.
Objectives: To describe the characteristics of C. amycolatum infection in patients with COM, evaluating its antibiotic susceptibility and resistance patterns.
Materials and methods: A retrospective study was conducted on patients diagnosed with COM who had positive cultures for C. amycolatum between June 2022 and February 2025 at a secondary care center. Microbiological results, including susceptibility and resistance profiles, were analyzed using descriptive statistics.
Results: During the study period, a total of 93 ear cultures were analyzed, of which 18 were positive for Corynebacterium species, including 12 cases of C. amycolatum. Eight had a single positive culture, while four had multiple positive cultures. C. amycolatum coexisted with other bacteria in eight cultures, 62% of which were coagulase-negative Staphylococcus. High resistance rates were observed for trimethoprim/sulfamethoxazole (100%), clindamycin (90%), levofloxacin (86.6%), and gentamicin (89%), while 100% susceptibility was noted for cefotaxime, cefepime, vancomycin, tetracycline, tigecycline, and linezolid.
Conclusions: C. amycolatum is an emerging pathogen in…
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