Acute Ingestion of a Mixed Flavonoid and Caffeine Supplement Increases Energy Expenditure and Fat Oxidation in Adult Women: A Randomized, Crossover Clinical Trial (OR29-07-19)
Abstract
Objectives
This randomized, double-blinded, crossover study measured the acute effect of ingesting a mixed flavonoid-caffeine (MFC) supplement compared to placebo (PL) on energy expenditure (EE) and fat oxidation (FATox) in a metabolic chamber with pre-menopausal women (N = 19, mean ± SD, age 30.7 ± 8.0 y, BMI 25.7 ± 3.4 kg/m2).
Methods
The MFC supplement (678 mg flavonoids, split dose 8:30 am, 1:00 pm) contained quercetin (200 mg), green tea catechins (368 mg, 180 mg EGCG), and anthocyanins (128 mg) from bilberry extract, and 214 mg caffeine. Participants were measured twice in a metabolic chamber for a day, 4 weeks apart, with primary outcomes including EE for 5 defined time segments and 22 h (22hEE, 8:30-6:30 am), substrate utilization from the respiratory quotient (RQ), physical activity counts, and plasma caffeine levels (4:00 pm). Areas under the curve (AUC) for metabolic data from the MFC and PL trials were calculated for 5 time segments using the trapezoid rule, with a mixed linear model (GLM) used to evaluate the overall treatment effect, and paired t-tests used to compare data for each time segment.
Results
EE and oxygen consumption for the MFC trial were significantly higher than PL (p < 0.001) when AUCs were compared as a whole and for each defined segment except during sleep. 22hEE with MFC was significantly higher than PL (1582 ± 143, 1535 ± 154 kcal/d, respectively, P = 0.003), with an average trial difference of 46.4 ± 57.8 kcal/d. Activity counts were not…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 19 participants or records.
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