The effects of a (poly)phenol-rich food intervention on markers of exercise-induced inflammation and oxidative stress: A randomised controlled trial
Abstract
This study examined whether consuming a (poly)phenol-rich food before strenuous muscle-damaging exercise can modify post-exercise markers of inflammation and oxidative stress. Using a double-blinded, randomised, placebo-controlled, between-subjects design, 26 recreationally active males (n = 15) and females (n = 11) consumed higher-(poly)phenol (H-POL) foods (dates, dark chocolate, pomegranate; 285.1 mg/day) or lower-(poly)phenol foods (L-POL) (cereal bar, milk chocolate, sports drink; 88.3 mg/day) for 3 days before, and then 30 min before, strenuous exercise (100 drop jumps, 50 squat jumps). A range of blood markers associated with inflammation (total and differential leukocytes, interleukin (IL)-6, IL-10, IL-1β, IL-2, IL-4, IL-12, tumour necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), monocyte chemoattractant protein-1 (MCP-1), granulocyte colony-stimulating factor), and oxidative stress (glutathione peroxidase (GPX), 4-hydroxynonenal (4-HNE), and urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG)) were quantified pre, immediately post, 1 and 2 h post-exercise. One hundred and nineteen plasma (poly)phenol metabolites were measured pre, immediately post and 1 h post-exercise. Total plasma (poly)phenol concentrations were greater in the H-POL vs. L-POL intervention, peaking 1 h post-exercise (H-POL: 239.5 ± 87.8 µM vs. L-POL 58.9 ± 33.8 µM; P < 0.001). There were interaction effects for IL-10 and TNF-α but no differences with post hoc tests. Urinary 8-OHdG excretion was…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 15 participants or records.
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