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Clinical Utility of Polymerase Chain Reaction (PCR) in Diagnosing and Managing Bacterial Infections: A Case Series of Three Patients With Acinetobacter baumannii

Ibrahim J, Stone RJ, Jacobsen T, Norman R

Cureus, 2025

Abstract

This case series highlights the critical role of polymerase chain reaction (PCR) in diagnosing and managing bacterial infections in dermatology. We present three cases of patients with the same bacterial infection, identified through PCR, and discuss the implications for treatment. The series highlights the advantages of PCR over traditional culture methods, emphasizing its ability to deliver rapid, accurate diagnoses and facilitate targeted therapeutic interventions. Unlike cultures, which can be time-consuming, PCR provides a quicker and more precise identification of pathogens. Additionally, we outline the cost-saving potential of PCR, as its efficiency in pinpointing infections can reduce the need for broad-spectrum antibiotics, minimize unnecessary diagnostic procedures, and shorten the duration of patient illness, thereby contributing to overall healthcare savings.

How strong is the evidence?

Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.

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