Dietary quercetin intake is not associated with risk of metabolic dysfunction-associated steatotic liver disease in a general adult population
Abstract
BACKGROUND: Metabolic dysfunction associated steatotic liver disease (MASLD) is the most common liver disease threatening public health. Quercetin is considered a promising candidate for treating and preventing MASLD, due to its antioxidant and anti-inflammatory properties. However, few studies have evaluated the association of daily quercetin intake with the risk of MASLD in the general population.
METHODS: This prospective cohort study included 16,746 adults. Dietary quercetin intake was assessed using a validated food frequency questionnaire. Incident MASLD cases were ascertained annually by liver ultrasound and cardiometabolic risk factors. Multivariable Cox proportional-hazards models were used to evaluate the association between quercetin intake and the risk of MASLD.
RESULTS: The data from 16,746 participants, with an average follow-up time of approximately 3.47 years, were analyzed and 3,544 participants developed MASLD during follow-up. After Multivariable adjustment, the hazard ratio (95% confidence interval) for MASLD across increasing quartiles of quercetin intake was 1.00 (reference), 0.93 (0.85, 1.03), 1.01 (0.91, 1.12), and 1.04 (0.92, 1.17) (P for trend = 0.35). Similarly, the adjusted hazard ratio (95% confidence interval) for MASLD across increasing quartiles of energy density and per-unit-kilogram-body-weight intake was 1.00 (reference), 0.99 (0.89, 1.09), 0.98 (0.89, 1.09), 1.02 (0.92, 1.13) (P for trend = 0.77), and 1.00 (reference), 0.92 (0.84, 1.01),…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 16,746 participants or records.
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