Comparative analysis of the effectiveness of various intensive care algorithms and their impact on cerebral complications in elderly patients with burn injuries and clinical sirs
Abstract
Abstract. Оbjective: to compare three approaches to intensive care in patients aged ≥65 years with burn injuries and SIRS and their impact on the frequency of cerebral complications.
Materials and methods. A prospective cohort clinical randomized open-label study was conducted for 60 patients aged 65–85 years with II–III degree thermal burns. All had clinically confirmed SIRS. Patients were randomized into three groups: group I – intensive care was provided according to the local protocol, group II – L-arginine hydrochloride solution was added to the local protocol, and group III – corvitin solution, a complex of quercetin and povidone, was added to the local protocol. The incidence of delirium according to CAM, the incidence of seizures, and long-term consequences—long-term cognitive impairment and acute stroke—were determined.
Results: There was a twofold decrease in the number of patients with delirium according to CAM in group III compared to group I, and a 30% decrease in group II compared to group I. The same trend was observed when assessing the incidence of seizures in patients of all groups during hospitalization. Thirty days after discharge from the hospital, cognitive dysfunction was recorded in 48% of patients in group I, 28% in group II, and 16% in group III. No cases of acute stroke were recorded in any patients in groups I, II, and III within 30 days after discharge.
Conclusions. In elderly patients with burn trauma and clinical SIRS, the addition of…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 60 participants or records.
Read the paper
Related studies
- Quercetin Influences Quorum Sensing in Food Borne Bacteria: In-Vitro and In-Silico Evidence
- Phenolic-protein interactions: insight from in-silico analyses – a review
- In Silico Discovery of Candidate Drugs against Covid-19
- Neuropharmacological Effects of Quercetin: A Literature-Based Review
- In vitro and in silico anti-dengue activity of compounds obtained from Psidium guajava through bioprospecting
- Effect of Quercetin Rich Onion Extracts on Bacterial Quorum Sensing
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.