Processes of free radical oxidation in therapy for patients with odontogenic phlegmons in maxillo-facial area in the presence of ischemic heart disease
Abstract
A large cohort of scientists is dealing with the issue of improving the treatment of maxillofacial odontogenic phlegmons. The course of these diseases is impacted by a significant number of factors, one of which is ishemic heart disease. Quercetin is a powerful antioxidant with a pronounced antioxidant effect. The use of 2-ethyl-6-methyl-3-hydroxypyridine succinate leads to increased oxidation of components, that is, to a synergistic antioxidant effect.
The purpose of this study is to enhance the therapy of odontogenic phlegmons of maxillofacial area in patients with ishemic heart disease through the combined use of drugs with antioxidant, antihypoxant and angioprotective effects.
Materials and methods. 80 patients with odontogenic phlegmon of maxillofacial area were examined. The participants were categorized into the following groups: Group 1 received parenteral quercetin, Group 2 received a combination of quercetin and intravenous administration of 2-ethyl-6-methyl-3-hydroxypyridine succinate, Group 3 received standard treatment (20 individuals), and Group 4 (control) comprised individuals without concomitant pathology who received the treatment according to a standard protocol (20 patients). To analyze the state of free radical oxidation processes in blood serum, the content of diene conjugates was studied.
Results. The level of diene conjugates was increased when compared to the control group by 93.2%, 95.0% and 96.2% for the 1st, 2nd and 3rd clinical groups,…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 80 participants or records.
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