Increasing Dietary Quercetin Intake Reduces Stroke Risk and Improve Long‐Term Survival in Chronic Kidney Disease Patients
Abstract
Quercetin has anti‐inflammatory properties. This study aims to explore the association between dietary quercetin intake, stroke risk, and long‐term survival in chronic kidney disease (CKD) patients. The analysis included 2001 CKD participants from National Health and Nutrition Examination Survey (NHANES) 2007–2010 and 2017–2018, with a weighted total population of 25,005,023. A weighted logistic regression model, restricted cubic splines (RCS) curve, weighted COX proportional hazards model, subgroup analysis, and Kaplan–Meier curve were constructed to comprehensively analyze the relationship between dietary quercetin intake and stroke prevalence as well as long‐term survival. At the same time, propensity score matching (PSM) was used to reduce the influence of confounding factors. After adjusting for all covariates, for every 1 mg/day increase in dietary quercetin intake, the prevalence of stroke decreases by 4% (OR = 0.96, 95% CI: 0.92–1.00). The RCS curve indicates that the protective effect of dietary quercetin intake on the prevalence of stroke is a linear relationship. Moreover, subgroup analysis indicated that the protective effect of dietary quercetin intake on the prevalence of stroke might be achieved by reducing inflammation. Meanwhile, for every 1 mg/day increase in dietary quercetin intake, the mortality decreases by 2% (HR = 0.98, 95% CI: 0.96–1.00). This observational cohort study showed that increased dietary quercetin intake is associated with reduced stroke…
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