Effect of transcription factor modulators on carbohydrates and lipid metabolism in rats after laparatomy under lipopolysaccharide-induced systemic inflammatory response
Abstract
This study is devoted to investigating the effect of NF-κB and Nrf2, transcription factor modulators, on markers of surgical stress and acute phase response, carbohydrate and lipid metabolism in the case of abdominal surgical trauma (laparotomy) under lipopolysaccharide (LPS)-induced systemic inflammatory response (SIR). The study was performed on 28 white Wistar male rats weighing 220-250 g, divided into 4 groups: 1st (control) included "pseudo-operated" animals; 2nd group involved rats, who underwent laparotomy following the LPS-induced SIR modelling; the animals of the 3rd, 4th and 5th groups subjected to laparotomy following LPS-induced SIR then for 7 days received ammonium pyrrolidinedithiocarbamate, an NF-κB activation inhibitor, in a dose of 76 mg/kg, dimethyl fumarate, an N inducer, in a dose of 15 mg / kg in 10% dimethyl sulfoxide solution, and a water-soluble form of quercetin in a dose of 100 mg/kg that is 10 mg/kg in terms of quercetin. The measurements were carried out in 7 days after the false surgical operation or laparotomy. It has been found out that the use of ammonium pyrrolidine dithiocarbamate, dimethyl fumarate, and water-soluble form of quercetin under the combined effects of surgical trauma (laparotomy) and S. typhi LPS significantly reduces the concentration of cortisol in blood plasma and the content of ceruloplasmin in the blood serum, lowers the level of hyperglycemia and hypertriacylglycerolemia.
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