Associations between flavonoids intake and sleep disorders: A survey-weighted cross-section study from NHANES.
Abstract
This study aimed to evaluate the associations between flavonoid intake and sleep disorders. A cross-sectional study was conducted using data from the National Health and Nutrition Examination Survey (2007-2010, 2017-2018). Intake data for 29 flavonoids were derived from the average of two 24-hour dietary recall interviews. Sleep disorders and sleep duration were the outcome measures. Dummy variables were used to account for missing covariate values. Survey-weighted generalized linear models and survey-weighted restricted cubic splines were applied to explore the associations between flavonoid intake and sleep disorders/sleep duration. Sensitivity and stratified analyses were performed to verify the robustness of results and examine potential subgroup differences. A total of 10,162 participants were included. After adjusting for covariates, isorhamnetin intake was inversely associated with sleep disorders. The odds ratios (OR) for sleep disorder were 0.944 (95% CI: 0.893-0.999) for continuous isorhamnetin intake and 0.754 (95% CI: 0.651-0.874; Ptrend<.001) for the highest tertile. Luteolin intake, both continuous and in tertiles, was also significantly inversely associated with sleep disorders (continuous OR = 0.903, 95% CI: 0.822-0.991; tertiles OR = 0.851, 95% CI: 0.732-0.989; Ptrend = .031). Isorhamnetin intake, categorized by tertiles, was positively correlated with sleep duration (β = 0.125, 95% CI: 0.042-0.208; Ptrend = .004), with a nonlinear relationship identified…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 10,162 participants or records.
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