Antioxidant quercetin levels in SUB-fertile MEN and their association with oxidative stress
Abstract
Background: Oxidative stress contributes significantly to male sub-fertility, underscoring the importance of antioxidants in improving semen quality. The primary objective of this study was to evaluate in vivo levels of antioxidant quercetin in sub-fertile men. Methods: This cross-sectional study was conducted over a period of 6 months at Imran Idrees Teaching Hospital Sialkot, Pakistan. The study population consisted of 44 males, divided into two groups: 11 healthy fertile controls and 33 sub-fertile men. The study group was further subdivided into those diagnosed with varicocele (n=11) and those without varicocele (n=22). Semen samples were collected following 3–4 days of abstinence in a sterile environment through masturbation. Semen analysis was performed according to WHO criteria, and sperm morphology was assessed using Kruger’s strict criteria. Quercetin levels in semen were measured using High-Performance Liquid Chromatography (HPLC). Data analysis was conducted using SPSS, with One-way ANOVA employed for variable comparisons and Scheffe’s test for correlation studies. Results: Healthy controls had higher sperm counts (80.09±5.40 million/mL) and motility (77.73±3.72%) than sub-fertile men with varicocele (14.00±4.02 million/mL, 30.18±7.13%) or without varicocele (23.55±3.17 million/mL, 34.77±6.51%) (p<0.001). Quercetin levels were significantly higher in controls (865.84±227 ?g/mL) compared to study group (p<0.05). Conclusion: This study confirms the presence of…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 22 participants or records.
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