Adjunctive EGb 761 treatment in patients with Parkinson's disease: a case series
Abstract
Background: Parkinson's disease (PD) is the second most common neurodegenerative disease. It is based on a gradual decrease in the number of dopaminergic neurons in the midbrain. Since various pathological processes, including oxidative stress, neuroinflammation, and impaired neuroplasticity, are involved in PD pathogenesis, there is increasing interest in adjunctive therapies that target multiple pathways. This study aims to provide a preliminary assessment of the effects of adjunctive EGb 761 on motor, cognitive, and molecular markers in patients with Parkinson's disease, to gain insights valuable for the design of future controlled and randomized clinical trials.
Methods: The study included 17 patients with Parkinson's disease who received EGb 761 for 1 month in the context of baseline antiparkinsonian therapy. Standard clinical and neurophysiological tests were performed: UPDRS, MMSE, MoCA, FAB, BDI-I, Spielberger-Hanin Anxiety Scale and Hoehn and Yahr scale, motor tempo and sensorimotor response; the following molecular genetic markers were determined: relative average telomere length, relative mtDNA copy number; and biochemical markers: LDH, SOD and CAT activity, as well as AGEs, GSH/GSSG and MDA concentrations were determined.
Results: Statistically significant changes in the relative number of mtDNA copies (decrease), GSH/GSSG (decrease) and MDA (increase), as well as a trend towards telomere elongation were observed.
Conclusion: EGb 761 administration in combination…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 17 participants or records.
Read the paper
Related studies
- Quercetin Influences Quorum Sensing in Food Borne Bacteria: In-Vitro and In-Silico Evidence
- Phenolic-protein interactions: insight from in-silico analyses – a review
- In Silico Discovery of Candidate Drugs against Covid-19
- Neuropharmacological Effects of Quercetin: A Literature-Based Review
- In vitro and in silico anti-dengue activity of compounds obtained from Psidium guajava through bioprospecting
- Effect of Quercetin Rich Onion Extracts on Bacterial Quorum Sensing
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.