Multitarget protection by Chinese herbal medicines against sensorineural hearing loss: a focus on oxidative stress, apoptosis, and inflammation
Abstract
Objective: Based on the molecular mechanisms of sensorineural hearing loss (SNHL), this study aims to explore the role of traditional Chinese medicine (TCM) in the treatment of SNHL, promote the development of deafness-related research, provide new insights for the formulation and medication of TCM in the treatment of SNHL, and further facilitate the better development of new drugs for clinical application.
Methods: Relevant literatures on sensorineural hearing loss (SNHL) and its treatment with traditional Chinese medicine (TCM) were reviewed. The pathogenesis of SNHL and the related research achievements of TCM in treating this disease were sorted out, and the existing research conclusions were analyzed and summarized.
Results: Sensorineural hearing loss (SNHL) is a type of hearing impairment mainly caused by damage to cochlear hair cells, spiral neurons, and/or the auditory center, including drug-induced deafness, noise-induced deafness, and age-related deafness. Its molecular mechanisms mainly involve apoptosis, oxidative stress injury, immune inflammation, and metabolic disorders. Due to the irreversibility (non-regeneration) of hair cells and spiral neurons, there is currently no effective treatment for hearing loss caused by such damage. In recent years, the use of traditional Chinese medicine (TCM) to treat hearing disorders by regulating the above-mentioned molecular mechanisms has gradually become a research hotspot, and a large number of studies have confirmed…
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