Curcumin, Diallyl Sulphide, Quercetin and Gallic Acid Uses as Anticancer and Therapeutic Agents for Breast Cancer: Current Strategies and Future Perspectives
Abstract
Globally, Breast cancer is a complex and common disease. 12.5 % of all new annual cancer cases worldwide. In 2020 there were 2.3 million women with breast cancer diagnosed and 685,000 died globally. For long time, breast cancer treatments options include surgery, chemotherapy, hormone therapy and radiotherapy. However adverse effects from treatment options are frequently reported and multidrug resistance, fever, weakness, allergy and the absence of treatment for metastasis are the main issues with breast cancer treatment. Due to their safety, dietary bioactive molecules have become effective tools for the treatment and prevention of cancer cell lines and animal models in recent years. It has been demonstrated that the compunds curcumin, diallyl sulfide, quercetin and gallic acid which are used as Indian spice and widely consumed fruits, suppress the growth of breast cancer cells and trigger apoptosis. The effects of curcumin, diallyl sulfide, quercetin and gallic acid in the combat against breast cancer are covered in this review. These agents have been shown to have effects both in vitro and in vivo.
How strong is the evidence?
Evidence Hub reads this as a review, done in animal and cell cultures (in vitro), not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Quercetin Influences Quorum Sensing in Food Borne Bacteria: In-Vitro and In-Silico Evidence
- Phenolic-protein interactions: insight from in-silico analyses – a review
- In Silico Discovery of Candidate Drugs against Covid-19
- Neuropharmacological Effects of Quercetin: A Literature-Based Review
- In vitro and in silico anti-dengue activity of compounds obtained from Psidium guajava through bioprospecting
- Effect of Quercetin Rich Onion Extracts on Bacterial Quorum Sensing
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.