Pimenta racemosa extract ameliorates chemically induced ulcerative colitis in rats by suppressing inflammation and oxidative stress
Abstract
Pimenta racemosa (P. racemosa) tree leaves are used in traditional medicine to alleviate flatulence and gastrointestinal disorders. Ulcerative colitis (UC) is a gastrointestinal inflammatory disease with well-known inflammatory and immunoregulatory pathological features. The complexity of the disease requires multi-targeted treatment. Because of their relative safety and effectiveness, natural products can be utilized as adjunct and alternative agents to conventional UC treatment. So, the present work aimed to isolate phenolic constituents of the plant’s 80% aqueous methanol extract (AME) and evaluate its protective effect on acetic acid-induced ulcerative colitis (UC) in rats. The defatted AME was chromatographed, and structures of the isolated compounds were elucidated using UV, NMR spectroscopy and HPLC–ESI–MS analysis. Induction of ulcerative colitis was done using Acetic acid, the protective effect against ulcerative colitis was supported by histopathological and immunohistochemical examinations. The isolated compounds are Kaempferol 3-O-β-D-glucopyranoside (kaempferol 3-O-glucoside) or (Astragalin) (1), quercetin 3-O-β-D-glucopyranoside (Isoquercetrin) (2), Quercetin (3), Catechin (4), quercetin 3-O-α-L-rhamnospyranoside (Quercetrin) (5). The AME of P. racemosa significantly alleviated the UC by decreasing the disease activity index and Wallace score. Additionally, GSH, CAT, and SOD were increased, and MDA was decreased, suggesting AME’s antioxidant activity. The…
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