First documented case of Siphonobacter curvatus bloodstream infection in an elderly patient with biliary abnormalities and suspected immune dysregulation
Abstract
Background: Siphonobacter curvatus is a recently identified species within the genus Siphonobacter and has not been previously reported in human infections.
Case presentation: We report the first documented case of bloodstream infection caused by S. curvatus in a 73-year-old female with biliary abnormalities and suspected immune dysregulation. The pathogen was identified using 16S rRNA sequencing after MALDI-TOF MS and VITEK 2 failed to classify it. Empiric therapy with ceftriaxone and levofloxacin was administered, and MIC values suggested potential antimicrobial activity; the patient subsequently made a full recovery.
Conclusion: This case highlights the diagnostic challenges posed by rare pathogens and underscores the importance of molecular diagnostics and MIC data in guiding clinical management.
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Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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