Severe pneumococcal pneumonia with human rhinovirus/enterovirus coinfection leading to sepsis in a welder: a case report
Abstract
Human rhinovirus/enterovirus (HRV/HEV) members of the Picornaviridae family are traditionally associated with self-limiting upper respiratory tract infections. However, increasing evidence suggests their potential to involve the lower respiratory tract and contribute to severe pulmonary disease. HRV/HEV infections are frequently complicated by bacterial coinfection and the development of complicated pneumonia. This case report presents a case of a 64-year-old male welder admitted to the intensive care unit with severe right lobar pneumonia and profound hypoxemia. Microbiological investigations confirmed invasive pneumococcal disease with Streptococcus pneumoniae bacteremia, alongside concomitant HRV/HEV infection. This viral-bacterial interplay induced a dysregulated systemic inflammatory response along with coagulopathy, respiratory failure, and other multiorgan dysfunction, fulfilling Sepsis-3 criteria. Despite early initiation of targeted intravenous antibiotic therapy, the clinical course was prolonged and fluctuating. This case highlights the potential severity of human rhinovirus/enterovirus coinfection with invasive pathogens such as Streptococcus pneumoniae, contributing to complicated pneumonia and sepsis. It also underscores the increased susceptibility of welders-particularly those with additional risk factors such as smoking and inadequate vaccination-to invasive pneumococcal disease. Early recognition of viral-bacterial coinfection and prompt management of…
How strong is the evidence?
Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Association of lower urinary tract symptoms and OAB severity with quality of life and mental health in China, Taiwan and South Korea: results from a cross-sectional, population-based study
- Ten-Day Quadruple Therapy Comprising Low-Dose Rabeprazole, Bismuth, Amoxicillin, and Tetracycline Is an Effective and Safe First-Line Treatment for Helicobacter pylori Infection in a Population with High Antibiotic Resistance: a Prospective, Multicenter, Randomized, Parallel-Controlled Clinical Trial in China
- The Role of the NLR and PLR in Urinary Tract Infection
- Threat of Antimicrobial Resistance among Pilgrims with Infectious Diseases during Hajj: Lessons Learnt from COVID-19 Pandemic
- Leclercia adecarboxylata urinary tract infection in a patient with bladder cancer and recurrent hematuria
- A Case Series of Staphylococcus lugdunensis Infection in Cancer Patients at an Academic Cancer Institute in the United States
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.