Comparison of Early Changes in Ocular Surface and Inflammatory Mediators Among Lenticule Extraction, Laser in Situ Keratomileusis and Femtosecond Laser-assisted Laser in Situ Keratomileusis
Abstract
To evaluate the short-term changes in ocular surface measures and tear inflammatory mediators after lenticule extraction (FLEx), laser in situ keratomileusis (LASIK) and femtosecond laser-assisted laser in situ keratomileusis (FS-LASIK) procedures.
Conditions: Myopia, Astigmatism.
Primary outcome: scale of Schirmer I test; scale of corneal fluorescein staining; scale of noninvasive tear breakup time; questionnaire of ocular surface disease index; scale of central corneal sensitivity; scale of tear meniscus height; concentration of Interleukin-1α; concentration of tumor necrosis factor-α; concentration of nerve growth factor; interferon-γ; concentration of transforming growth factor-β1; concentration of matrix metalloproteinase-9.
Enrollment: 75 participants.
How strong is the evidence?
Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 75 participants or records.
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