Postoperative Antibiotic Management Duration Following Surgery for Intravenous Drug Abuse (IVDA) Endocarditis (OPTIMAL)
Abstract
The purpose of this study is to determine the safety and compliance of initial intravenous (IV) antibiotics followed by oral antibiotic therapy following uncomplicated IVDA endocarditis. Endocarditis has a high rate of sickness and death, involves a long hospitalization and a long-term use of IV antibiotics necessitating six (6) weeks of in-patient hospital stay, and comes with a high cost.
Conditions: Endocarditis.
Primary outcome: All-cause Mortality at Six (6) Months Post-surgery.; All-cause Mortality at (12) Months Post-surgery.; Incidence of Recurrent Blood Culture Positive Infection (6 Month); Incidence of Recurrent Blood Culture Positive Infection (1 Year); Incidence of Cardiac Re-operation (6 Month); Incidence of Cardiac Re-operation (1 Year).
Enrollment: 5 participants.
How strong is the evidence?
Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 5 participants or records.
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