Short-term comparative study of the effects of preserved and unpreserved topical levofloxacin on the human ocular surface
Abstract
PURPOSE: To compare the short-term effects of preserved and unpreserved topical levofloxacin on the ocular surface of preoperative patients with age-related cataracts.
METHODS: This was a prospective, randomized, double-blind, parallel-group study. Patients who were going to undergo cataract surgery received either preserved topical levofloxacin (with 0.01% benzododecinium bromide [BOB]) or unpreserved topical levofloxacin instilled 4 times per day in a short-term course preoperatively. Enzyme-linked immunosorbent assay (ELISA) for MUC5AC, symptom scoring, tear film break-up time (BUT), corneal fluorescein staining, Schirmer I test, and conjunctival impression cytology were performed before and after the medication.
RESULTS: Sixty-two patients (62 eyes) who completed the final evaluation were included in the data analysis. Before the medication, there was no statistically significant difference (p > .05) between the 2 groups in terms of all the subjective symptoms and objective tests. After the medication, no statistically significant difference (p > .05) was observed in the scoring of each symptom between the 2 groups. With regard to BUT, corneal fluorescein staining, Schirmer I test, and conjunctival impression cytology, the 2 groups also demonstrated similar results and showed no significant difference (p > .05). In addition, the amounts of MUC5AC in the tear samples of patients with preexisting BUT ≤5 seconds were similar in the 2 groups and no significant difference was…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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