Gastro retentive floating drug delivery system of levofloxacin based on Aloe vera hydrogel: In vitro and in vivo assays
Abstract
Gastro retentive drug delivery systems (GRDDS) have gained immense popularity as they reduce dosing frequency, improve bioavailability, and enhance patient compliance. Herein, a plant-based, controlled swelling, and pH-sensitive GRDDS based on Aloe vera hydrogel and cellulose was developed for the sustained release of levofloxacin (LEVO). The properties of five various floating tablet formulations including dynamic swelling, pH-responsiveness, hardness, friability, drug release, and buoyant time were evaluated. The optimized formulation (FF) was characterized using FTIR and SEM, and the surface morphology exhibited a porous texture with microchannels that facilitated tablet swelling and prolonged release of LEVO. The formulation FF remained buoyant (> 12 h) in the simulated gastric fluid with a buoyancy time of 303 s. A pH-dependent swelling behavior of the formulation FF was revealed with the highest swelling (7.1 g/g) in water, followed by buffers of pH 6.8 (5.4 g/g), 4.5 (3.8 g/g), and 1.2 (2 g/g). The controlled release of LEVO was demonstrated for >12 h following the Hixson-Crowell model and non-Fickian diffusion. Pharmacokinetic parameters of LEVO were determined using in vivo studies. The non-toxic nature of the formulation under study was demonstrated. The results render this approach promising in reducing the dosing frequency, suggesting its potential for clinical applications.
Read the paper
Related studies
- Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model
- Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli
- Photochemical behavior of levofloxacin
- Correlation Between Dissolution Profiles of Salt-Form Drugs in Biorelevant Bicarbonate Buffer and Oral Drug Absorption: Importance of Dose/ Fluid Volume Ratio
- Evaluation of the synergistic potential and mechanisms of action for de novo designed cationic antimicrobial peptides
- Synthesis of [11C]levofloxacin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.